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Regeneration of Tissues in the Dental-Craniofacial Complex

2021

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Fresia R, Marangoni P, Burstyn-Cohen T and Sharir A‡. (2021). From bite to byte: Dental structures resolved at a single-cell resolution. Journal of Dental Research. Accepted 19-Feb-2021

2020

Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Alzamora MDP, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein O, Tuveson D, Braun BS, Shannon K‡. (2020). KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice. JCI Insight. 29:140495.

2019

Sharir A, Marangoni P, ZilionisR, Wan M, Wald T, Hu J, Kawaguchi K, Epstein L, Harrington K, Pagella P, Mitsiadis T, Siebel CW, Klein AM‡ and Klein OD‡. (2019). A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage. Nature Cell Biology. 21;1102-1112.
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2018

Chase RR, Carter AC, Salhotra A, Marecic O, Lopez ML, Sharir A, Wan DC, Klein OD, Chang HY‡, and Longaker MT‡. (2018). Mechanoresponsive stem cells acquireneural crest fate in jaw regeneration. Nature. 563;514-521.
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Ching ST, Infante CR, Du W, Sharir A, Park S, Menke DB, Klein OD‡. (2018). Isl1 mediates mesenchymal expansion in the developing external genitalia via regulation of Bmp4, Fgf10, and Wnt5a. Hum Mol Genet. 27: 107–119.
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2016

Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss LA, Ullian EM‡. (2016). Human iPS cell-derived neurons uncover the impact of increased Ras signaling in Costello Syndrome. J Neurosci. 6:142-52.

Sharir A and Klein OD‡. (2016). Watching a deep dive: Live imaging provides lessons about tooth invagination. J Cell Biol. 214(6):645-7.

2015

Bauer O, Sharir A, Kimura A, Hantisteanu S, Takeda S, Groner Y‡. (2015). Loss of osteoblast Runx3 produces severe congenital osteopenia. Mol Cell Biol. 35:1097-109.

Mushegyan V, Eronen JT, Lawing AM, Sharir A, Janis CM, Jernvall J, Klein OD‡ (2015). Continuously Growing Rodent Molars Result from a Predictable Quantitative Evolutionary Change over 50 Million Years. Cell Rep. 11:67380.

Stern T, Aviram R, Rot C, Galili T, Sharir A, Kalish, Achrai N, Keller Y, Shahar R, Zelzer E‡. (2015). Isometric Scaling in Developing Long Bones Is Achieved by an optimal epiphyseal growth balance. PLoS Biol. 13: e1002212.

2014

Goodwin AF, Tidyman WE, Jheon AH, Sharir A, Zheng X, Charles C, Fagin JA, McMahon M, Diekwisch TG, Ganss B, Rauen KA, Klein OD‡. (2014). Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation. Hum Mol Genet. 23:682-92.
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2013

Blitz E, Sharir A, Akiyama H, Zelzer E‡. (2013). Tendon-bone attachment unit is formed modularly by a distinct pool of Scx- and Sox9-positive progenitors. Development. 140:2680-90.

Sharir A, Milgram J, Dubnov-Raz G, Zelzer E, Shahar R‡. (2013). A temporary decrease in mineral density in perinatal mouse long bones. Bone. 6:197-205.

2011

Mahamid J, Sharir A, Zelzer E, Addadi L and Weiner S‡. (2011). Bone mineralization proceeds through intracellular amorphous calcium phosphate loaded vesicles: A cryo electron microscopy study. Journal of Structural Biology. 174: 527-35.

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Sharir A‡ and Zelzer E. (2011). TGF-β in Tendon: The Path from Muscle Force to ECM Composition. Current Biology. 21: R472-4.

Sharir A, Israeli D, Milgram J, Currey J.D, Monsonego-Ornan E and Shahar R‡. (2011). The canine baculum: The structure and mechanical properties of an unusual bone. Journal of Structural biology. 175: 451-6.
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Sharir A, Ramniceanu G, and Brumfeld V‡. (2011). High resolution 3D imaging of exvivo biological samples by micro–CT. Journal of Visual Experiments. 52. 2699, doi: 10.3791/2688

Sharir A, Stern T, Rot C, Shahar R and Zelzer E‡. (2011). Muscle force regulates bone shaping for optimal load-bearing capacity during embryogenesis. Development. 138: 3247-59.

2010 & Earlier

Lyashenko N, Weissenböck M, Sharir A, Erben RG, Minami Y and Hartmann C‡. (2010). Mice lacking the orphan receptor ror1 have distinct skeletal abnormalities and are growth retarded. Dev Dyn. 239: 2266-77.

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Shipov A, Sharir A, Zelzer E, Milgram J, Monsonego-Ornan E and Shahar R‡. (2010). The influence of severe prolonged exercise restriction on the mechanical and structural properties of bone in an avian model. Vet J. 183: 153-60.

Vandoorne K, Magland J, Plaks V, Sharir A, Zelzer E, Wehrli F, Hemmings BA, Harmelin A and Neeman M‡. (2010). Bone vascularization and trabecular bone formation are mediated by PKB alpha/Akt1 in a gene-dosage-dependent manner: in vivo and ex vivo MRI. Magn Reson Med. 64: 54-64.

Barak M.M, Sharir A and Shahar R‡. (2009). Optical metrology methods for mechanical testing of whole bones. Vet J. 180: 7-14.

Blitz E, Viukov S, Sharir A, Shwartz Y, Galloway JL, Pryce BA, Johnson RL, Tabin CJ, Schweitzer R and Zelzer E‡. (2009). Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of BMP4 at the tendon-skeleton junction. Dev Cell.17: 861-73.

Chattah NL, Sharir A, Weiner S and Shahar R‡. (2009). Determining the elastic modulus of mouse cortical bone using electronic speckle pattern interferometry (ESPI) and micro computed tomography: a new approach for characterizing small-bone material properties. Bone. 45: 84-90.

Kahn J, Shwartz Y, Blitz E, Krief S, Sharir A, Breitel DA, Rattenbach R, Relaix F, Maire P, Rountree RB, Kingsley DM and Zelzer E‡. (2009). Muscle contraction is necessary to maintain joint progenitor cell fate. Dev Cell. 16: 734-43.

Mahamid J, Sharir A, Addadi L and Weiner S‡. (2008). Amorphous calcium phosphate is a major component of the forming fin bones of zebrafish: Indications for an amorphous precursor phase. PNAS. 105: 12748-53

Reich A*, Sharir A*, Zelzer E, Hacker L, Monsonego-Ornan E and Shahar R‡. (2008). The effect of weight loading and subsequent release from loading on the postnatal skeleton. Bone. 43: 766-774. *equal contribution.

Sharir A, Barak M.M and Shahar R‡. (2008). Whole bone mechanics and mechanical testing. Vet J. 177:8-17.
Link

Shivtiel S, Kollet O, Lapid K, Schajnovitz A, Goichberg P, Kalinkovich A, Shezen E, Tesio M, Netzer N, Petit I, Sharir A and Lapidot T‡. (2008). CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules. J Exp Med. 205: 2381-95.

Amarilio R, Viukov SV, Sharir A, Eshkar-Oren I, Johnson RS and Zelzer E‡. (2007). HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis. Development. 134: 3917-3928.

Sharir A, Milgram J and Shahar R‡. (2006). Structural and functional anatomy of the neck musculature of the dog (Canis familiaris). J Anat. 208: 331–351.

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